Prevalence of Insulin Injection-induced Lipodystrophy and Associated Risk Factors in Children and Adolescents With Type 1 Diabetes Mellitus

Background: Lipodystrophy is the most common complication of insulin injection that has not been studied yet in children with Type 1 Diabetes Mellitus (T1DM) Isfahan. Objectives: This study aimed to evaluate prevalence injection-induced lipodystrophy based on related risk factors and adolescents T1DM. Methods: In this cross-sectional study, aged less than 18 years T1DM who referred endocrinology clinic Imam Hossein Hospital Isfahan, Iran, 2019 were enrolled. The baseline, anthropometric, T1DM-related characteristics patients recorded. was diagnosed by clinical examination. without compared. association between disease-related investigated. Results: 194 (88 boys 106 girls) 3 evaluated. 91 (46.9%), which 64 (33%) had grade 1, 24 (12.4%) 2, (1.5%) lipodystrophy. There a significant difference frequency age, BMI, patient education, parent site, duration diabetes, site change, needle dose, HbA1c, hypoglycemia (P<0.05). Regression analysis indicated there presence HbA1c (P<0.001, t=7.20), dose t=4.47), BMI t= -3.78) (P=0.002, t=3.15). Conclusions: we reported high among From factors, lower using insulin, uncontrolled diabetes (HbA1c>7) important for